NitroimidazoleCAS e theko e tlaase: 527-73-1, 2-NITROIMIDAZOLE
Kenyelletso ea Sehlahisoa
Lebitso la Senyesemane:2-Nitroimidazole
CAS:527-73-1
Litšoantšiso: 11a;amicin;AZOMYCIN;ro05-9129;AZOMYCINE;2-NITROMIDAZOLE;2-nitro-imidazo;2-Nitroimidaxole;WLN: T5M CNJ BNW;2-NITROIMIDAZOLE
Sebaka sa ho qhibiliha: 287 ° C (dec) (lit.)
Sebaka se belang: 211.75 ° C
Boima ba 'mele: 1.5988
Lethathamo la refractive: 1.4264
Maemo a polokelo: Sehatsetsing
Solubility: NH4OH: soluble50mg/mL, e hlakileng, yellowtoorange
Ponahalo
PKA :8.72±0.10(E boletsoeng esale pele)
Mmala: Lightyellowtokhaki – tala
Lits'ebetso tsa Lik'hemik'hale: kristale e 'mala o mosehla o khanyang.Sebaka se qhibilihang 283 ℃ (ho bola).E qhibiliha ka methanol, ethanol, acetone, ethyl acetate, ha e qhibilihe ka har'a ether, chloroform.
Sebelisa:
Bohareng ba Misonidazole, radiosensitizer ea oncology, e sebelisoa e le organic synthesis intermediate.
E sebelisoa ho lokisa nitroimidazole-substituted boric acid e le selelekela sa litšoantšo tsa hypoxic tishu.E boetse e sebelisoa ho lokisa li-radiosensitizer tse fumanehang sebakeng sa marang-rang bakeng sa lihlahala tse ruileng ka li-receptor tsa estrogen.
Etsa kopo
Nitroimidazole (2-nitroimidazole) ke thepa e tala ea mantlha bakeng sa ho kopanya le ho etsa metsoako ea nitroimidazole ka li-radiosensitizer tsa electronophilic.Li-derivatives tse nkeloang sebaka ke N tse lokiselitsoeng ho tsoa ho 2-nitroimidazole li sebelisitsoe joalo ka anti-tumor radiosensitizers lithutong tsa bongaka.2. Chemicalbook-based nitroimidazole ke ea bohlokoa lipakeng tsa mefuta e fapaneng ea radiotherapy sensitizers bakeng sa lihlahala, tse kang Misonidazole, pimonidazole, etanidazole, joalo-joalo.
Tšimoloho: Hlahala e kotsi ke lefu le tloaelehileng le behang bophelo ba motho kotsing.Hoo e ka bang karolo ea 70 ho ea ho 80 lekholong ea lihlahala tsena e hloka phekolo ea mahlaseli.Li-radiosensitizer li hohetse tlhokomelo e ngata ho radiotherapy ka lebaka la bokhoni ba tsona ba ho eketsa kutlo ea lisele tsa tumor ho radiation.2-nitroimidazole ke ea bohlokoa lipakeng bakeng sa mefuta e fapaneng ea radiotherapy sensitizers bakeng sa mofetše, joalo ka Misonidazole, pimonidazole, etanidazole, joalo-joalo 2-nitroimidazole e ke ke ea etsoa ka nitrification e tobileng ea imidazole, e hlahisang 4 (5) -nitroimidazole, empa eseng. 2 - nitroimidazole.
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